Diabetic patients are at high risk of acute kidney injury(AKI)and chronic kidney disease(CKD).AKI can accelerate the progression of CKD,while CKD increases the incidence and severity of AKI.Inflammatory cytokines play an important role in the transition from AKI to CKD in diabetic patients,but their mechanisms differ between AKI and CKD.In the early stage of AKI,pro-inflammatory cytokines(such as IL-1β,IL-18,TNF-α,etc.)predominate and aggravate renal injury;in the recovery stage of AKI or CKD,pro-fibrotic cytokines(such as TGF-β,etc.)predominate and promote renal interstitial fibrosis.Inflammatory cytokines affect renal structure and function by inducing apoptosis,EMT and autophagy of renal tubular epithelial cells,EndoMT of endothelial cells,and activating interstitial cells to secrete matrix components.Interventions targeting inflammatory cytokines provide new insights for blocking the transition from AKI to CKD in diabetic patients.
NETL
NSTL
万方数据
