Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease,and additional nutritional support contributes to alleviate IBD symptoms.Studies have shown that dietary n-3 polyunsaturated fatty acids possess anti-inflammatory activity,while clinical trials have reported that additional supplementation with n-3 polyunsaturated fatty acids does not alleviate the disease symptoms in some IBD patients.Large-scale sequencing has revealed mutations in the n-3 polyunsaturated fatty acids receptor gene free fatty acid receptor 4(FFAR4).It remains unclear whether the variable effects of n-3 polyunsaturated fatty acids in IBD treatment are associated with the absence of the FFAR4 gene.In this study,the wild type(WT)and FFAR4 knockout(FFAR4KO)mice were used to establish the colitis models,concurrently supplemented with n-3 polyunsaturated fatty acids.The results showed that compared to those WT mice,the FFAR4KO mice exhibited more severer colitis under simultaneous n-3 polyunsaturated fatty acids supplementation,characterized by greater weight loss,higher disease activity index(DAI),increased colonic myeloperoxidase(MPO)activity,and higher mRNA levels of colonic inflammatory factors.This study provides a theoretical basis for precise nutritional intervention in IBD patients.
万方数据
维普
