Effect of Lactobacillus gasseri with Different Bacteriocins Production on the Intestinal Micro-Ecology in Mice
It has been reported that Lactobacillus gasseri produces a variety of bacteriocins that inhibit a few kinds of food pathogenic bacteria,but there are few researches on how bacteriocins affect the interaction between Lactobacillus gasseri and the intestinal microecology.This study utilized the in silico prediction of bacteriocin operon,antibacterial experiment with six strains of food-borne pathogenic bacteria as indicators and liquid chromatograph mass-spectrometer/mass spectrometer analysis to prove that Lactobacillus gasseri FNMGHLBE6L1,FNMGHLBE20L5 and FHNFQ16L5 produced different bacteriocins.Through the animal experiments,the effects of three bacteriocin-producing Lactobacillus gasseri strains on the intestinal microecology of the mice were investigated.The diversity and profile of the gut microbiota were dramatically influenced by all three strains of Lactobacillus gasseri,and the level of colonic interleukin-1β was also significantly decreased.In summary,the gut microbiota was significantly affected by bacteriocin-producing Lactobacillus gasseri,and the variations in effects among strains were associated with their bacteriocin production.This study could serve as a guide for future research on the relationship between various bacteriocin-producing Lactobacillus gasseri and the gut microbiota.
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