食品与生物技术学报2024,Vol.43Issue(10) :21-31.DOI:10.12441/spyswjs.20240626002

益生菌对食源性脂质代谢紊乱相关疾病的缓解作用及机制研究进展

Research Progress on the Alleviating Effects and Mechanisms of Probiotics on Diet-Induced Lipid Metabolism Disorders

顾敏雯 刘皓文 祝晨昕 丁思琪 姚源玥 崔洁 李文慧 张健 姜金池 胡永红
食品与生物技术学报2024,Vol.43Issue(10) :21-31.DOI:10.12441/spyswjs.20240626002

益生菌对食源性脂质代谢紊乱相关疾病的缓解作用及机制研究进展

Research Progress on the Alleviating Effects and Mechanisms of Probiotics on Diet-Induced Lipid Metabolism Disorders

顾敏雯 1刘皓文 2祝晨昕 2丁思琪 1姚源玥 1崔洁 2李文慧 2张健 2姜金池 3胡永红3
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作者信息

  • 1. 南京工业大学生物与制药工程学院,江苏 南京 211816
  • 2. 南京工业大学食品与轻工学院,江苏 南京 211816
  • 3. 南京工业大学食品与轻工学院,江苏 南京 211816;南京工业大学材料化学工程国家重点实验室,江苏 南京 211816
  • 折叠

摘要

食源性脂质代谢紊乱会引发多种疾病,已经逐渐成为全球性的公共卫生问题.越来越多的研究表明,益生菌具有调节脂质代谢的功效,因此挖掘具有预防和改善食源性脂质代谢紊乱相关疾病潜力的益生菌具有广阔的应用前景.作者概述了益生菌对食源性脂质代谢紊乱引起的肠道菌群失衡、炎症性肠病和免疫力下降的缓解作用,从肠-肝轴循环、关键代谢物质和菌株自身特性等角度阐述了益生菌对食源性脂质代谢的调控机制,为开发具有调节食源性脂质代谢紊乱功效的益生菌提供参考.

Abstract

Diet-induced lipid metabolism disorders are associated with a variety of diseases and have gradually become a global public health concern.An increasing number of studies have demonstrated that probiotics exhibit regulatory effects on lipid metabolism,highlighting their potential in preventing and mitigating diseases related to such disorders.The author provides a comprehensive overview of the alleviating effects of probiotics on gut microbiota dysbiosis,inflammatory bowel disease,and decreased immunity caused by diet-induced lipid metabolism disorders.The regulatory mechanisms of probiotics on lipid metabolism is elaborated from some perspectives including the gut-liver axis,key metabolic substances,and strain-specific characteristics.This review offers insights and references for developing probiotics with efficacy in modulating diet-induced lipid metabolism disorders.

关键词

益生菌/脂质代谢/肠-肝轴/短链脂肪酸/胆汁酸

Key words

probiotics/lipid metabolism/gut-liver axis/short-chain fatty acid/bile acids

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出版年

2024
食品与生物技术学报
江南大学

食品与生物技术学报

CSTPCD北大核心
影响因子:0.674
ISSN:1673-1689
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