Effect of Temperature on the Twist and Stretch Elasticity of dsRNA:An All-Atom Molecular Dynamics Simulation
Using an all-atom molecular dynamics simulation approach,this paper focuses on the behavior of the stretch and twist elasticity of double-stranded RNA(dsRNA)and the coupling between them as a function of temperature.The results show that the stretch and twist moduli decrease linearly with increasing temperature.These elasticity coefficient components decrease almost linearly,thus highlighting the increased flexibility of dsRNA at high temperatures.In addition,the twist-stretch coupling coefficient decreases with increasing temperature,exhibiting a negative correlation,suggesting that stretch induces a decrease in the twist angle.This paper also describes the underlying biophysical mechanisms and confirms the findings with the existing literature.
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