In order to study the aerodynamic interference of nacelles on wings of large turboprop aircraft,the effects of nacelles'aerodynamic interference on stall characteristics and maximum lift coefficient of aircraft are firstly analyzed,the flow mechanism of nacelles'aerodynamic interference is summarized,and then the engineering application is analyzed based on practical cases.The results show that the aerodynamic effects of nacelle on the wings are mainly manifested in the stalling characteristics and the maximum lift coefficient.The optimized design of nacelle control profile can effectively improve aircraft stall characteristics.The aerodynamic effect of the nacelle on wings can meet the design expectation by adjusting the position and strength of the vortex between nacelle and wing leading edge.The results provide some methods for improving the aerodynamic interference of large turboprop nacelles on wings.