It is well known that suitable exercise benifits our cells and overal health,however,the molecular mechanisms remain largely unknown.Which tissues,organs,cells,and molecular targets are affected by exercise?How health and disease are affected by exercise?These questions still keep unanswered.Exploring these questions are quite important for us to present better,intelligent,and personalized exercise prescription.Therefore,understanding the changed molecules during exercise is thus critical.For this purpose,National Institutes of Health co-funded"The Molecular Transducers of Physical Activity Consortium"(MoTrPAC),which aims to identify the molecule profiles affected by exercise and provide a data basis for a series of scientific questions.This paper will introduce the background,current status,and future perspective of MoTrPAC.