首页|Authentication and distinction of Shenmai injection with HPLC fingerprint analysis assisted by pattern recognition techniques

Authentication and distinction of Shenmai injection with HPLC fingerprint analysis assisted by pattern recognition techniques

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In this paper, the feasibility and advantages of employing high performance liquid chromatographic (HPLC) fingerprints combined with pattern recognition techniques for quality control of Shenmai injection were investigated and demonstrated. The Similarity Evaluation System was employed to evaluate the similarities of samples of Shenmai injection, and the HPLC generated chromatographic data were analyzed using hierarchical clustering analysis (HCA) and soft independent modeling of class analogy (SIMCA). Consistent results were obtained to show that the authentic samples and the blended samples were successfully classified by SIMCA, which could be applied to accurate discrimination and quality control of Shenmai injection. Furthermore, samples could also be grouped in accordance with manufacturers. Our results revealed that the developed method has potential perspective for the original discrimination and quality control of Shenmai injection.

Shenmai injectionHigh performance liquidchromatographyFingerprintPattern recognition

Xue-Feng Lu、Kai-Shun Bi、Xu Zhao、Xiao-Hui Chen

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School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang 110016, China

参麦注射液 指纹图谱分析 模式识别技术 HPLC 认证 高效液相色谱 质量控制 评价系统

National Key Scientific Project for New Drug Discovery and Development of China

Grant 2009ZX09301-012

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(5)
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