首页|Pre-concentration and determination of amitriptyline residues in waste water by ionic liquid based immersed droplet microextraction and HPLC

Pre-concentration and determination of amitriptyline residues in waste water by ionic liquid based immersed droplet microextraction and HPLC

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This paper describes a new approach for the determination of amitriptyline in wastewater by ionic liquid based immersed droplet microextraction (IL-IDME) prior to highperformance liquid chromatography with ultraviolet detection. 1-Hexyl-3-methylimidazolium hexafluorophosphate ([C6MIM][PF6]) was used as an ionic liquid. Various factors that affect extraction, such as volume of ionic liquid, stirring rate, extraction time, pH of the aqueous solution and salting effect, were optimized. The optimal conditions were as follows: microextraction time, 10 min; stirring rate, 720 rpm; pH, 11; ionic drop volume, 100 uL; and no sodium chloride addition. In quantitative experiments the method showed linearity in a range from 0.01 to 10 ug/mL, a limit of detection of 0.004 ug/mL and an excellent pre-concentration factor (PF) of 1100. Finally, the method was successfully applied to the determination of amitriptyline in the hospital wastewater samples.

AntidepressantIonic liquid based immersed droplet microextraction (IL-IDME)High performance liquid chromatography(HPLC)

M.T. Hamed Mosavian、Z. Es＇haghi、N. Razavi、S. Banihashemi

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Chemical Engineering Department, Ferdowsi University of Mashhad, Mashhad, Iran

Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran

Chemistry Department, Faeulty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

高效液相色谱法 离子性液体 残留量测定 萃取时间 液体浸泡 液滴 废水 预浓缩

authors wish to acknowledge the useful help of Chemical Engineering Research Lab (CERL), Ferdowsi University of Mashhad, Eng

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(5)
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