首页|Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

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Liquid chromatography (LC) is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past several years, small particle size packing materials have been introduced by several column manufacturers to enable fast and efficient LC separations. Several examples of pharmaceutical analyses, including impurity profiling of taxanes and atracurium besylate, in-process testing of peptides in injectable dosage form, using sub-2 um column technology are presented in this paper, demonstrating some of the capabilities and limitations of the technology.

Liquid chromatographyUPLCPharmaceuticalTaxaneAtracurium besylatePeptides

Marie-Josee Rocheleau、Elaine Larouche、Cristina Salamu、Mihaela Curca

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Now at Endoceutics Inc., 1405 Boulevard du Parc Technologique Quebec City, QC GIP 4P5, Canada.

Now at Groupe Parima, 4450 Cousens, Montr6al, QC H4S IX6 Canada.

Omega Laboratories Ltd., 11177 Hamon, Montreal, QC H3M 3E4, Canada

液相色谱分离 测试过程 杂质分析 注射用 药物 高分辨率 包装材料 氨氯地平

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(5)
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