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Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system

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The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets.

Aspirin delayed-releasetabletsDrug dissolution testFiber-optic dissolution systemUV-vis spectrum

Yan Wang、Ping-Ping Xu、Xin-Xia Li、Kun Nie、Ming-Fu Tuo、Bin Kong、Jian Chen

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Department of Pharmacy, Xinjiang Medical University, Urumqi 830054, China

Xinjiang FOCS Bio-Tech Co., Ltd., Urumqi 830011, China

阿司匹林 水解过程 延迟释放 溶解速率 溶出度 试验 片剂 系统

Xinjiang Medical University Scientific Innovation FundXinjiang Uygur Autonomous Region Natural Science Fund

XJC2011292011211A041

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(5)
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