首页|Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

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In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentra- tion with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.

RactopamineUniformly-sizedmolecularly imprintedpolymersSolid-phase extractionMulti-step swelling andpolymerizationSeparation andenrichment

Ya Li、Qiang Fua、Meng Liu、Yuan-Yuan Jiao、Wei Du、Chong Yu、Jing Liu、Chun Chang、Jian Lu

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Faculty of Pharmacy, School of Medicine, Xi＇an Jiaotong University, Xi＇an 710061, PR China Department of Pharmacy, Northwest Hospital, Xi＇an 710004, PR China

Faculty of Pharmacy, School of Medicine, Xi＇an Jiaotong University, Xi＇an 710061, PR China

Faculty of Pharmacy, School of Medicine, Xi＇an Jiaotong University, Xi＇an 710061, PR China Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China

Xian Yang Central Hospital, Xian Yang 71200, PR China

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分子印迹聚合物 莱克多巴胺 生物样品 Scatchard分析 富集 分离 均匀 二甲基丙烯酸酯

National Natural Science Foundations of ChinaNational Natural Science Foundations of China

3087319381173024

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(6)
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