首页|Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu tablet

Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu tablet

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A simple, sensitive and accurate method based on high performance liquid chromato- graphy (HPLC) with diode array detector (DAD) was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu (XKS) tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet.

Fingerprint analysisQuality evaluationMulti-ingredient quanti-tative analysisXinkeshu tabletHigh-performanceliquid chromatography

Pei Wang、Lian Li、Hailong Yang、Shijuan Cheng、Yingzi Zeng、Lei Nie、Hengchang Zang

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National Glycoengineering Research Center and School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China

Shandong Wohua Pharmaceutical Limited Company, No. 519 Liyuan Road, Weifang 261205, China

色谱指纹图谱 质量评价方法 定量分析 二极管阵列检测器 高效液相色谱法 化学成分含量 平板电脑 相似性

Major Projects of Independent Innovation Achievements of Shandong Provincepartly by the Scientific and Technolo- gical Projects of Shandong ProvinceIndependent Innovation Foundation of Shandong UniversityShandong Province Natural Science Foun- dation, China

2010ZDZX1A04062009GG100020812010TS054ZR2011HM080

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(6)
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