首页|An analytical method for Fe(Ⅱ) and Fe(Ⅲ) determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex

An analytical method for Fe(Ⅱ) and Fe(Ⅲ) determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
A robust voltammetric method has been developed and validated for the determination of Fe(Ⅱ) and Fe(Ⅲ) in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe(Ⅱ) and Fe(Ⅲ) composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex.

Sodium ferric gluconatecomplexIron sucrose complexIron polysaccharidesVoltammetry

Daniele Merli、Antonella Profumo、Carlo Dossi

展开 >

Dipartimento di Chimica, Universita degli Studi di Pavia, Via Taramelli 12/14/16, 27100 Pavia Italy

Dipartimento di Scienze Teoriche ed Applicate （DSTA）, Universita dell＇Insubria, Via Dunant, 7, 21100 Varese Italy

葡萄糖酸亚铁 Fe 测定 医药级 蔗糖 脉冲极谱法 铁配合物 低分子量

FAR, Fondo Ateneo per la Ricerca Universitfi di Pavia, Italy. We thank Prof. Nick Serpone for useful discussions

2012

西安医科大学学报(英文版)
西安交通大学

西安医科大学学报(英文版)

影响因子：0.07
ISSN：1671-8267
年,卷(期)：2012.2(6)
  • 4
  • 14