首页|New chiral reverse phase HPLC method for enantioselective analysis of ketorolac using chiral AGP column
New chiral reverse phase HPLC method for enantioselective analysis of ketorolac using chiral AGP column
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A simple, specific, precise, sensitive and rapid reverse phase-HPLC method was developed for determination of ketorolac enantiomers, a potent nonnarcotic analgesic in pharmaceutical formulations. The method was developed on a chiral AGP column. Mobile phase was 0.1 M sodium phosphate buffer (pH 4.5): lsopropanol (98:2, v/v), at a flow rate of 1 mL/min with run time of 15 min. Ultraviolet detection was made at 322 nm. The linearity range was 0.02 10 μg/mL for each of the enantiomers. The mobile phase composition was systematically studied to find the optimum chromatographic conditions. Validation of the method under the conditions selected showed that it was selective and precise and that the detector response was linear function of ketorolac.
R-KetorolacS-KetorolacChiralAGPRP-HPLC
Sunil K. Dubey、Jangala Hemanth、Chiranjeevi Venkatesh K.、R.N. Saha、S. Pasha
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Department of Pharmacy, Birla Institute of Technology ＆ Science, Pilani, India
Institute of Genomics and Integrative Biology, Mall Road, Delhi, India
反相高效液相色谱法 酮咯酸 AGP 对映体 选择性分析 手性 流动相组成 紫外检测波长
authors are thankful to University Grant Commission, New Delhi for extending their financial support
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