Collagen is the most abundant protein in the human body and provides strength,elasticity and structure to various tissues in the body.The mechanical properties,thermal stability,hydrophobicity and antioxidant properties of collagen can be enhanced by innovative cross-linking techniques,including chemical,physical and enzymatic cross-linking.In this paper,based on the review of a large number of domestic and international literature,we mainly describe the methods of physical crosslinking of collagen,elucidate the role and significance of collagen modification,and introduce the applications of modified collagen.Finally,it looks forward to the prospects and challenges of collagen cross-linking modification.
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