Objective:To observe the quality of life with uterine wedge resection and traditional hysterectomy patients after operation. Methods:in 120 cases in our hospital for a hysterectomy patients as the research object, randomly divided into two groups, the control group used the tra-ditional abdominal hysterectomy, the observation group USES the small open uterine body wedge resection, two groups were observed and compared after 6 months of physical and mental health, relieve the symptoms of dysmenorrhea quality and the degree of sexual life, menopause. Results: The observation group patients physical and mental health situation better than the control group (P < 0.05), the symptoms of menopause is shorter than that of control group (P<0.05), the quality of life is higher than that of control group (P<0.05), with statistical sig-nificance. The observation group mitigation dysmenorrhea score was 4.68 ± 0.25, 4.51± 0.42 in the control group, no significant difference (P>0.05). Conclusion:Line to hysterectomy patients with small open wedge resection of the uterus, postoperative life quality less negative effect, worth clinical promotion.