Objective:To summarize the nursing methods of total knee arthroplasty patients. Methods:9 patients were given preoperative psycho-logical nursing, postoperative rehabilitation training and careful nursing, prevention and treatment of postoperative complications and step functions exercise guidance. Results:9 patients incision healed, no infection, good recovery of knee joint function. Conclusion:on the basis of the nursing of artificial total knee replacement patients, is an important factor to ensure the success of total knee arthroplasty.