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代谢工程在生物丁醇生产中的应用及研究进展

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传统的丁醇发酵由于其产量和产率都较低,制约了生物丁醇的发展.代谢工程以系统生物学为基础,为生物丁醇生产菌种的改造提供了合理的依据.介绍了丁醇发酵的菌种与丁醇的生物合成途径,综述了代谢工程方法在生物丁醇生产中的应用及其最新研究进展,并对其应用前景进行了展望.
Application and research progress of metabolic engineering in butanol production
The low yield and productivity of butanol in the traditional fermentation inhibit the development of biobutanol industry. Metabolic engineering, which is based on the systems biology, provides a reasonable basis for the strain manipulation. This paper introduces the biosynthetic pathways of the butanol and summarizes the application and latest research progress of metabolic engineering in butanol production. The prospect of biobutanol application is also proposed.

metabolic engineeringbiobutanolmetabolic networkmetabolic flux analysisfermentation

闫永亮、刘宏娟、张建安

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清华大学核能与新能源技术研究院,北京100084

代谢工程 生物丁醇 代谢网络 代谢流分析 发酵

国家自然科学基金

21176141

2012

现代化工
中国化工信息中心

现代化工

CSTPCDCSCD北大核心
影响因子:0.553
ISSN:0253-4320
年,卷(期):2012.32(4)
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