The effects of different reaction conditions on the morphology and particle size of ZnO nanoparticles prepared in the microreactor are introduced,and specific applications of the microfluidic devices used for integration of ZnO nanoparticles in the fields of biosensing,catalytic degradation and bio-separation are reviewed.The application of the microreactor in the mass production of ZnO is briefly described.It is shown through analysis that the microfluidic technique provides a new way for the development of ZnO nanomaterials with specific morphology and functionalization.Meanwhile,the synthesis of three dimensional ZnO nanoparticles enriches the diversity of nanomaterials.However,current research work mainly concentrates in the laboratory level,and the problems such as product deterioration and high cost faced in scale-up production still need to be solved by researchers.