Objective To investigate the current situation of falls in patients with amyotrophic lateral sclerosis(ALS)and analyze the influencing factors.Methods A total of 110 ALS patients admitted to Department of Neurology of Peking University Third Hospital from February to April 2023 were selected as the research objects by the convenient sampling method.The Self-designed Patient General Data and Disease-related Questionnaire and Morse Fall Scale(MFS)were used for questionnaire investigation.Results A total of 100 ALS patients were included,and the incidence of falls in ALS patients was 45.0%(45/100).Binomial Logistic regression analysis showed that gait abnormality,high risk of fall and abnormal muscle strength of lower extremity were risk factors for fall in ALS patients(P<0.05).Conclusions Abnormal gait,high risk of falls and abnormal lower limb muscle strength are independent factors affecting falls in ALS patients,and they are important aspects in preventing and managing falls in ALS patients.