Based on the development process,definition,design types,and application status in the domestic medical and health field of real-world study,this paper explored the current situation and application prospects of real-world study in clinical nursing research,aiming to inspire nursing researchers to explore the current status of real-world nursing based on real-world study concepts,and provide practical basis for the formation of practical guidelines and technical specifications for the high-quality development of clinical nursing,so as to improve the quality of patient nursing services.