Objective To summarize the best evidence for the prevention and management of oral mucosal pressure injury(OMPI)in severe neurological patients with tracheal intubation.Methods The clinical decisions,guidelines,expert consensus,evidence summary,systematic reviews,and clinical practice regarding the prevention and management of OMPI in severe neurological patients with tracheal intubation were searched in domestic and foreign databases,guideline websites,and professional association websites.The search period was from database establishment to May 30,2023.Four researchers who undergone systematic evidence-based training conducted literature quality evaluation and evidence extraction.Results A total of 15 articles were included,including three evidence summaries,three systematic reviews,two guidelines,three clinical practices,three expert consensus,and one clinical decision.A total of 27 pieces of best evidence were summarized from six aspects of risk assessment,oral mucosal assessment,oral nursing,tracheal intubation management,nutritional support,and organizational training.Conclusions The best evidence for the prevention and management of OMPI in severe neurological patients with tracheal intubation summarized provides evidence-based evidence for medical and nursing staff to prevent and manage OMPI in severe neurological patients with tracheal intubation.