中华现代护理杂志2024,Vol.30Issue(25) :3423-3430.DOI:10.3760/cma.j.cn115682-20231213-02569

老年恶性肿瘤患者疼痛对疲乏症状的影响:睡眠障碍和抑郁的平行中介作用

Impact of pain on fatigue symptoms in elderly malignant tumor patients:parallel mediating effects of sleep disorders and depression

高杰 胡慧秀 孙超 赵雅洁 王培
中华现代护理杂志2024,Vol.30Issue(25) :3423-3430.DOI:10.3760/cma.j.cn115682-20231213-02569

老年恶性肿瘤患者疼痛对疲乏症状的影响:睡眠障碍和抑郁的平行中介作用

Impact of pain on fatigue symptoms in elderly malignant tumor patients:parallel mediating effects of sleep disorders and depression

高杰 1胡慧秀 2孙超 2赵雅洁 3王培4
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作者信息

  • 1. 中国医学科学院北京协和医学院护理学院,北京 100144
  • 2. 北京医院护理部国家老年医学中心中国医学科学院老年医学研究院,北京 100730
  • 3. 北京医院心血管内科国家老年医学中心中国医学科学院老年医学研究院,北京 100730
  • 4. 北京医院肿瘤内科病房国家老年医学中心中国医学科学院老年医学研究院,北京 100730
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摘要

目的 从"症状群"视角构建平行中介模型,验证老年恶性肿瘤患者睡眠障碍和抑郁在疼痛与疲乏关系中的中介效应,探讨疲乏相关症状群内部症状的作用路径及作用关系.方法 采用便利抽样法,于2022年1-4月,选取北京医院312例老年恶性肿瘤患者作为调查对象,应用一般资料调查表、疼痛数字评定量表、匹兹堡睡眠质量指数、医院焦虑抑郁量表、癌症疲乏量表进行测量,采用Spearman相关分析探讨疼痛、疲乏、抑郁、睡眠障碍间的相关性,采用AMOS 24.0进行平行中介模型的构建,并采用Bootstrap方法进行中介效应检验.结果 本研究共发放问卷312份,回收有效问卷305份,有效回收率为97.76%.老年恶性肿瘤患者疼痛与疲乏呈正相关(r=0.436,P<0.01),与睡眠障碍呈正相关(r=0.316,P<0.01),与抑郁呈正相关(r=0.315,P<0.01);睡眠障碍与疲乏呈正相关(r=0.491,P<0.01);抑郁和疲乏呈正相关(r=0.587,P<0.01).中介作用模型包括两条路径:睡眠障碍和抑郁在疼痛与疲乏之间分别起到了部分中介作用,占总效应(0.544)的效应量分别为40.63%(0.221)和14.89%(0.081),总中介作用的效应量为55.51%,高于直接作用的效应量44.49%.结论 老年恶性肿瘤患者中疲乏相关症状群(疼痛、睡眠障碍、抑郁、疲乏)的内部中存在着疼痛-睡眠障碍-抑郁-疲乏的平行中介效应,医护人员可以通过改善患者的疼痛状况进而降低患者的睡眠障碍及抑郁症状来减轻疲乏症状.

Abstract

Objective To construct a parallel mediation model from the perspective of symptom clusters to verify the mediating effect of sleep disorders and depression in the relationship between pain and fatigue in elderly malignant tumor patients,and explore the pathways and relationships of the internal symptoms of fatigue associated symptom clusters.Methods From January to April 2022,convenience sampling was used to select 312 elderly patients with malignant tumors from Beijing Hospital as respondents.General Information Questionnaire,Numerical Rating Scale,Pittsburgh Sleep Quality Index,Hospital Anxiety and Depression Scale,and Cancer Fatigue Scale were used for measurement.Spearman correlation was used to explore the correlation between pain,fatigue,depression,and sleep disorders,AMOS 24.0 was used to construct a parallel mediation model,and Bootstrap method was used to test the mediating effect.Results A total of 312 questionnaires were distributed,and 305 valid questionnaires were collected,with an effective response rate of 97.76%.Pain of elderly patients with malignant tumors was positively correlated with fatigue(r=0.436,P<0.01),sleep disorders(r=0.316,P<0.01),and depression(r=0.315,P<0.01),sleep disorders were positively correlated with fatigue(r=0.491,P<0.01),and depression and fatigue were positively correlated(r=0.587,P<0.01).The mediation model included two pathways:sleep disorders and depression partially mediated the relationship between pain and fatigue,accounting for 40.63%(0.221)and 14.89%(0.081)of the total effect(0.544),respectively.The total mediating effect was 55.51%,which was higher than the direct effect of 44.49%.Conclusions There is a parallel mediating effect of pain-sleep disorder-depression-fatigue within the fatigue associated symptom cluster(pain,sleep disorders,depression,fatigue)in elderly malignant tumor patients.Medical and nursing staff can alleviate fatigue symptoms by improving the patient's pain condition and reducing their sleep disorders and depression symptoms.

关键词

肿瘤/老年人/疼痛/疲乏/睡眠障碍/抑郁/症状群/中介作用

Key words

Neoplasms/Aged/Pain/Fatigue/Sleep disorders/Depression/Syndrome cluster/Moderating effect

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基金项目

中央高水平医院科研业务费专项(BJ-2022-082)

泰康溢彩公卫基金年度资助课题()

出版年

2024
中华现代护理杂志
中华医学会

中华现代护理杂志

CSTPCD
影响因子:1.14
ISSN:1674-2907
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