Objective To explore the effectiveness of the O-AMAS teaching model in clinical teaching for blood purification training nurses.Methods Convenience sampling was used to select 187 training nurses from the Blood Purification Center of the First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 as research subjects.Eighty training nurses enrolled from January to December 2021 were selected as the control group,and 107 training nurses enrolled from January to December 2022 were selected as the experimental group.After three months of intervention,the training nurses'theoretical scores,operational skills assessment scores,and satisfaction were compared between the two groups.Results The theoretical and operational skills assessment scores of the experimental group were higher than those of the control group(P<0.05).The satisfaction of the experimental group with the teaching model,teaching effectiveness,completion of theoretical training,guidance on operational skills,and overall teaching was higher than that of the control group(P<0.05).Conclusions The O-AMAS teaching model for clinical teaching can help improve the training effectiveness and satisfaction of blood purification training nurses.