Objective To explore the effect of personalized training based on early start Denver model(ESDM)combined with applied behavior analysis(ABA)in children with autism spectrum disorder(ASD).Methods From January 2021 to January 2023,convenience sampling was used to select 90 children with ASD who received treatment at the Shaoxing Seventh People's Hospital and their caregivers as research subjects.The children were divided into two groups using a random number table method in a 1∶1 ratio.The control group received routine rehabilitation,while the observation group was treated with personalized training based on ESDM combined with ABA.Both groups were intervened for six months.Children's Autism Rating Scale(CARS),Autism Behavior Checklist(ABC),Gesell Developmental Schedule(GDS),Sign-Significate Relation(S-S)Language Development Delay Assessment,Social Life Ability Scale for Infant-Junior Middle School Students(S-M),and Modified Barthel Index(MBI)were used to evaluated the effects of intervention on two groups of ASD children before and after intervention.Results After six months of intervention,the CARS and ABC scores of ASD children in the observation group were lower than those in the control group,and the scores of GDS dimensions and total developmental quotient,S-S Language Development Delay Assessment score,S-M score,and MBI score were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusions Personalized training based on ESDM combined with ABA has a good effect,which can improve loneliness symptoms of children with ASD,alleviate cognitive,language,and behavioral dysfunction,enhance social adaptation ability and activities of daily living.