Objective To explore the application effects of whole-process nutritional management in patients undergoing thoracoabdominal laparoscopic radical esophagectomy.Methods A total of 144 patients who underwent thoracoabdominal laparoscopic radical esophagectomy at the Jiangsu Cancer Hospital between February 2022 and February 2024 were selected using convenience sampling method.Patients were randomly assigned to a control group(n=72)receiving routine care and an observation group(n=72)receiving whole-process nutritional management in addition to routine care.Nutritional status,postoperative recovery,nursing satisfaction,and weight loss were compared between the two groups.Results On the day before surgery,the Nutritional Risk Screening(NRS-2002)score of the observation group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).The observation group had earlier times to first ambulation,bowel movement,flatus,and fewer total complications compared to the control group,the differences were statistically significant(P<0.05).Nursing satisfaction scores in the observation group were significantly higher than in the control group,the differences were statistically significant(P<0.05).One month postoperatively,the observation group experienced less weight loss than the control group,the difference was statistically significant(P<0.05).Conclusions Whole-process nutritional management improves preoperative nutritional status scores,reduces postoperative complications and weight loss,and enhances patient satisfaction with nursing care in esophageal cancer patients undergoing thoracoabdominal laparoscopic radical esophagectomy.