摘要
目的 总结头颈部肿瘤患者放射性口腔黏膜炎预防和管理的最佳证据.方法 检索UpToDate、BMJ最佳临床实践、美国国立指南库、医脉通、美国国家综合癌症网、欧洲肿瘤协会、Cochrane Library、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、PubMed、Embase、Web of Science、中国知网、万方数据库、中国生物医学文献数据库等数据库和网站中关于头颈部肿瘤患者放射性口腔黏膜炎预防和管理的文献,包括临床决策、最佳实践、指南、专家共识、系统评价和证据总结,检索时限为建库至2023年11月30日.结果 共纳入18篇文献,包括6篇指南,2篇专家共识,8篇系统评价和2篇证据总结.最终从评估、药物预防、非药物预防、抗感染和镇痛管理、健康教育和多学科团队管理6个方面总结了 34条最佳证据.结论 本研究总结了头颈部肿瘤患者放射性口腔黏膜炎预防及管理的最佳证据.医护人员在选择、应用证据时需结合患者的自身特点、疾病情况及意愿.
Abstract
Objective To summarize the best evidence for preventing and managing radiotherapy-induced oral mucositis in patients with head and neck cancer.Methods The clinical decisions,best practices,guidelines,expert consensus,systematic reviews,and evidence summaries regarding the prevention and management of radiotherapy-induced oral mucositis in patients with head and neck cancer were retrieved from UpToDate,British Medical Journal(BMJ)Best Practice,Agency for Healthcare Research and Quality,Medlive,National Comprehensive Cancer Network,European Society for Medical Oncology,Cochrane Library,Joanna Briggs Institute(JBI)Evidence-Based Health Care Center Database,PubMed,Embase,Web of Science,China National Knowledge Infrastructure,WanFang Data,China Biology Medicine disc and so on.The search period was from database establishment to November 30,2023.Results A total of 18 articles were included,involving six guidelines,two expert consensus,eight systematic reviews,and two evidence summaries.Thirty-four best pieces of evidence were summarized from six aspects of assessment:drug prevention,non-drug prevention,anti-infection and analgesic management,health education,and multidisciplinary team management.Conclusions This study summarizes the best evidence for preventing and managing radiotherapy-induced oral mucositis in patients with head and neck cancer.Medical and nursing staff should consider the patient's characteristics,disease condition,and willingness when selecting and applying evidence.
维普
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