Objective To summarize evidence related to nutritional interventions for patients with chronic kidney disease(CKD)and protein-energy wasting(PEW),providing reference for clinical nursing practice.Methods An evidence-based question was developed,and relevant literature on nutritional interventions for CKD patients with PEW was systematically searched using the"6S"evidence model,with a search timeframe up to March 31,2024.Literature quality was independently assessed by two research nurses,with a senior nursing expert involved in decision-making.Evidence extraction,evaluation,and grading were conducted using the Joanna Briggs Institute(JBI)evidence pre-grading system.Results A total of 19 studies were included,including three clinical decisions,three guidelines,three expert consensus,four systematic reviews,five randomized controlled trial studies,and one national standard.Evidence was summarized across five dimensions:PEW assessment,PEW prevention,PEW treatment,specific dietary recommendations,and team collaboration,resulting in 43 best evidence recommendations.Conclusions The best evidence summarized in this study provides a foundation for clinical healthcare providers to develop nutritional intervention strategies for CKD patients with PEW.