Research on the Structure-Activity Relationship of the Hedgehog Signaling Pathway Inhibitor
The study has shown that cyclopamine is a kind of inhibitors of Hedgehog signal pathway and has a good effect on a wide variety of tu-mor. Proposes a solid QSAR model. The data contains 93 cyclopamine derivatives as well as their activities against four different cell lines (NCI-H446, BxPC-3, SW1990 and NCI-H157). And proposes different machine learning ways in order to get a better way to build a good Quantitative Structure-Activity Relationship. The testing indicates that the SVM is a better choice for building the QSAR model of inhibitors of Hedgehog signaling pathway.
CyclopamineInhibitors of Hedgehog Signaling PathwayQuantitative Structure-Activity Relationship
NETL
NSTL
万方数据
维普
