Construction and application research of equine Phenotype-Gene knowledge database based on knowledge graph
The equine phenotype-gene database provides auxiliary reference for genetic breeding and disease diagnosis and treatment of equines.The abstracts of related articles were extracted from biomedical literature database Pubmed,and the multi-entity recognition interface Pubtator was used for biological entity recognition.The equine gene-phenotype knowledge graph was constructed in a semi-automated manner by combining the public domain relationship extraction tool OpenIE and artificial annota-tion.The knowledge graph included 25 common phenotypes of equine,and 139 entities such as genes and variations associated with them and 177 semantic relationships were obtained.The Equine Phenotype-Gene Knowledge Graph frees equine researchers from tedious and time-consuming literature searches and facilitates further research,as well as providing a technical reference for constructing a complete equine knowledge graph.