背景：镁合金降解释放的镁离子是人体内的重要阳离子，除了参与生物体内多种新陈代谢外，还参与调节骨代谢活动，同骨组织的改建和稳定相关。机体内镁离子浓度的异常将导致骨代谢相关疾病。<br> 目的：回顾分析镁离子在骨代谢过程中的作用及机制，并对镁离子参与调节骨代谢相关因子及信号通路进行综述。<br> 方法：以“镁，骨代谢，PI3K/Akt信号通路，OPG/RANKL信号通路，TRPM和Wnt信号通路”为中文检索词，以“magnesium， osteoblast， bone metabolism， PI3K/Akt signal pathway， OPG/RANKL signal pathway， TRPM， Wnt signal pathway”为英文检索词，应用计算机检索中国期刊全文数据库、PubMed数据库及万方数据库2000年1月至2016年2月所有相关文章。<br> 结果与结论：镁合金骨内植入体在降解过程中释放的镁离子，可以通过调节骨代谢过程中的相关信号通路来影响骨代谢活动。目前研究发现，镁离子与骨代谢离子浓度变化时会引起信号通路中相关因子的变化，进而影响骨组织的新生和改建。而镁离子是否还可以通过其他途径影响骨代谢活动是今后研究的热点。
Molecular mechanism of magnesium ions in bone metabolism:research and progress
BACKGROUND:The magnesium ions released from the degradation of magnesium al oy are an important cation in human body, which not only participate in various metabolic activities, but also regulate bone <br> metabolism and involved in the reconstruction and stability of bone. Therefore, the abnormal concentration of magnesium ions can lead to bone metabolism related diseases. <br> OBJECTIVE:To review the function and mechanisms of magnesium ions in bone metabolism and overview the related cytokines and signaling pathways. <br> METHODS:A computer-based research of CJFD, PubMed and WanFang databases was performed for pertinent articls published from January 2000 to February 2016 using the keywords of“magnesium, bone metabolism, PI3K/Akt signal pathway, OPG/RANKL signal pathway, TRPM, and Wnt signal pathway”in Chinese and English, respectively. <br> RESULTS AND CONCLUSION:The magnesium ions released from the degradation of magnesium al oy expose influence on the bone metabolism by regulating the related signaling pathways. The concentration changes of magnesium ions can induce the changes in cytokines in the signaling pathways related to bone metabolism, and further act on the bone remodeling. Whether the magnesium ions participate in bone metabolism through other pathways wil be a hot spot.
国家科技期刊平台
NSTL
万方数据
维普
