Changes and prognostic significance of gingival crevicular fluid osteogenesis-related factors in patients with chronic periodontitis and dentition defect after oral implantation
Objective To investigate changes of osteogenesis-related factors in gingival crevicular fluid and their correlation with implant prognosis in patients with chronic periodontitis and dentition defect after oral implantation.Methods 92 patients with chronic periodontitis and dentition defects who received dental implant surgery(chronic periodontitis group)and 60 patients with periodontal healthy dentition defects who received dental implant surgery(control group)in our hospital were selected.The levels of osteogenesis-related factors alkaline phosphatase(ALP),runt-related transcription factor 2(RUNX2),osteocalcin(OCN)and osteoprotegerin(OPG)in gingival crevicular fluid were detected at 1 week,2 weeks and 1 month after operation,and the relationship between them and the prognosis of implants was analyzed.Results The levels of ALP,RUNX2,OCN and OPG in gingival crevicular fluid in the chronic periodontitis group were significantly lower than those in the control group at 2 weeks and 1 month after surgery(P＜0.05).The levels of ALP,RUNX2,OCN and OPG in gingival crevicular fluid in the good prognosis group were significantly higher than those in the poor prognosis group at 2 weeks and 1 month after surgery(P＜0.05).Multivariate Logistic regression analysis showed that the ALP(OR=0.771,95％CI:0.598-0.993)and OPG(OR=0.917,95％CI:0.842-0.999)at 2 weeks after surgery,and RUNX2(OR=0.828,95％CI:0.719-0.953)at 1 month after surgery was an independent factor of poor prognosis(P＜0.05),and the areas under the ROC curve for predicting poor prognosis were 0.765,0.728 and 0.820,respectively.Conclusion The changes trend of osteogenesis-related factors in gingival crevicular fluid in patients with chronic periodontitis and dentition defect after oral implantation were first increased and then decreased.The levels of ALP and OPG at 2 weeks after surgery and RUNX2 at 1 month after surgery were independent factors for the poor prognosis of implants.
万方数据
维普
