Expression of APP and BMPs in oral squamous cell carcinoma and their correlation with clinical pathological factors
Objective:To analyze the expression of amyloid precursor protein(APP)and bone morphogenetic proteins(BMPs)in oral squamous cell carcinoma(OSCC),and their correlation with clinical pathological factors.Methods:The expression levels of APP and BMPs in carcinoma tissues and normal adjacent tissues of 75 patients with OSCC were measured.Results:The positive expression rates of APP and BMP-2,and mRNA expression in OSCC tissues were higher than those in adjacent normal tissues(P<0.05).The expression of APP and BMP-2 was related to clinical stage and lymph node metastasis of OSCC(P<0.05).Clinical stage III,cervical lymph node metastasis,and high expression of APP mRNA and BMP-2 mRNA were risk factors for poor prognosis of OSCC(P<0.05).ConclusionAPP and BMPs are related to clinical stage and lymph node metastasis of OSCC.The two can be usedfor the prognosis.
国家科技期刊平台
NSTL
万方数据
