Value of general anesthesia induction with different doses of remimazolam onelderly patients undergoing laparoscopic surgery
Objective:To analyze the application value ofgeneral anesthesia induction with different doses of remimazolam onelderly patients undergoing laparoscopic surgery.Methods:130 patients wererandomlydivided into group 1(n=43),group 2(n=43),and group 3(n=44).All three groups were given general anesthesia induction withintravenou-sinjection ofremimazolam at the doses of 0.2,0.3 and 0.4mg/kg respectively.The differences in related indicatorswere compared among the three groups.Results:The number of cases with remimazolam remedy in group 1 was higher than that in groups 2 and 3(P<0.05).The time from the beginning of induction to BIS≤60 was shown as group 1>group 2>group 3(P<0.05).The levels of plasmaNE,E and Cor in group 1 were higher than those in group 2 and group 3 immediately aftertracheal intubation and at 5min aftertracheal intubation(P<0.05).At 5min after tracheal intubation,the HR and MAP in group 1 were higher than those groups 2 and 3(P<0.05).The incidencerates of adverse reactions in group 3were higher comapred with those in group 1 and group 2(P<0.05).Conclusion:0.3mg/kgof remimazolam is the appropriate dose for general anesthesia induction in elderly patients with laparoscopic surgery.
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