The Protective Effect of Penehyclidine Hydrochloride on Cerebral Infarction via the HMGB1 Pathway
Objective:To investigate the protective effect of penehyclidine hydrochloride on cerebral infarction based on the HMGB1 pathway.Methods:50 SD male rats were grouped to investigate the optimal dosage and effect of PHC in treating cerebral infarction,as well as to explore the role of the HMGB1 pathway.Results:PHC intervention can alleviate nerve cell damage,and its effect is correlated with the dosage.Compared with the sham operation group,multiple indicators in the model group and the PHC group are abnormal.However,compared with the model group,the indicators in the PHC group are improved,and the improvement is also related to the dosage.Inhibition of HMGB1 has the same effect as a high dose of PHC,which can improve brain tissue inflammation and oxidative stress,and reduce protein expression.PHC treatment is related to the inhibition of the HMGB1/TLR4/NF-κB pathway,and combined inhibition can enhance the effect..Conclusions:PHC has a protective effect on rats with cerebral infarction by inhibiting the HMGB1/TLR4/NF-κB pathway and downregulating the expression of inflammatory factors.
Penehyclidine hydrochlorideHigh mobility group histone B1Toll-like receptor 4Nuclear factor-κBCerebral infarction
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