摘要
目的:脑钠肽(BNP)联合血浆微小核糖核酸-21(miRNA-21)对冠心病(CHD)心肌缺血的诊断价值.方法:纳入 2020年 4月至2022年 3月于我院进行诊治的 141例疑似CHD心肌缺血患者,根据检查结果分为冠状动脉造影(CAG)阳性组(69 例)和CAG阴性组(72例).分析血清BNP、血浆miRNA-21 联合对CHD心肌缺血的诊断价值.结果:与CAG阴性组比较,CAG阳性组患者血清BNP、血浆miRNA-21显著升高,P均=0.001.经ROC曲线结果显示,BNP、miRNA-21及三项联合检测诊断CHD心肌缺血的曲线下面积(AUC)分别为 0.692、0.726、0.731、0.874.三项联合检测的AUC显著高于各项单独检测(P均=0.001).结论:BNP、miRNA-21联合能够显著提高对冠心病心肌缺血的诊断价值.
Abstract
Objective:To investigate the diagnostic value of myocardial ischemic attack duration,brain natriuretic peptide(BNP)combined with plasma miRNA-21 in myocardial ischemia in coronary heart disease(CHD).Methods:141 patients with suspected CHD myocardial ischemia who were treated in our hospital from April 2020 to March 2022 were included and divided into coronary angiography(CAG)positive group(69 cases)and CAG negative group(72 cases)according to the examination results.The diagnostic value of serum BNP and plasma miRNA-21 combined with the duration of myocardial ischemic episodes in the diagnosis of CHD myocardial ischemia was analyzed.Results:There was a notable increase in serum BNP[(93.38±9.55)pg/ml vs.(101.10±9.24)pg/ml],plasma miRNA-21[(3.55±0.48)vs.(4.08±0.85)],and myocardial ischemic episode duration[(240.15±41.12)s vs.(274.15±51.07)s]were considerably higher,both P=0.001.The results of the ROC curve demonstrated that the area under the curve(AUC)for the diagnosis of CHD myocardial ischemia by duration of myocardial ischemic episodes,BNP,miRNA-21,and the three combined tests were 0.692,0.726,0.731,and 0.874,respectively.The AUC of the three combined tests was significantly higher than those(P=0.001).Conclusion:BNP and miRNA-21 combined duration of myocardial ischemia can significantly improve the diagnostic value of myocardial ischemia in coronary heart disease.
国家科技期刊平台
NSTL
万方数据