结直肠癌免疫亲和蛋白家族相关基因预后模型的构建与验证
Construction and validation of a prognostic model for immunoaffinity protein family-related genes in colorectal cancer
王庆惠 1朱兴墅 1陈惠燕 2纪辉涛 1陈银珍 1黄国良 1赵虎 3王瑜3
作者信息
- 1. 福建中医药大学福总教学医院(第九〇〇医院)普通外科,福建福州 350025
- 2. 福建医科大学福总临床医学院(第九〇〇医院)普通外科,福建福州 350025
- 3. 福建中医药大学福总教学医院(第九〇〇医院)普通外科,福建福州 350025;福建医科大学福总临床医学院(第九〇〇医院)普通外科,福建福州 350025
- 折叠
摘要
目的:构建预测结直肠癌(colorectal cancer,CRC)总生存期的预后模型并验证.方法:从TCGA数据库下载CRC患者数据,通过COX和LASSO回归筛选关键基因.基于关键基因建立风险评分模型,采用该模型和TNM分期构建列线图.绘制校准曲线和时间依赖ROC曲线验证准确性.GSE87211为验证集.结果:FKBP2、FKBP5、FKBP8、FKBP9 和AIP与CRC患者预后相关,风险评分模型表明高风险患者的生存时间低于低风险患者,训练集与验证集时间依赖ROC曲线下面积分别为 0.859和 0.923.结论:该预后模型对CRC患者的预后预测提供一定价值.
Abstract
Objective:Construction and validation of a prognostic model for predicting overalsurvival in colorectal cancer(CRC).Methods:CRC patient data were downloaded from the TCGA database and key genes were screened by COX and LASSO regression.A risk score model was established based on the key genes,and a column-line graph was constructed using the model and TNM staging.Calibration curves and time-dependent ROCcurves were plotted to verify the accuracy.GSE87211 was the validation set.Results:FKBP2,FKBP5,FKBP8,FKBP9 and AIP were associated with the prognosis of CRC patients,and the risk scoring model indicated that the survival time of high-risk patients was lower than that of low-risk patients,and the area under the time-dependent ROC curves of the training and validation sets were 0.859 and 0.923,respectively.Conclusion:This prognostic model provides some value for prognostic prediction of CRC patients.
关键词
结直肠癌/预后模型/FKBP基因家族Key words
colorectal cancer/prognostic model/FKBP gene family引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据