低剂量18F-FDG全身PET/CT肿瘤显像可行性的临床研究
Clinical study on the feasibility of low-dose 18F-FDG whole-body PET/CT tumor imaging
朱丹丹 1何海月 1徐小凯1
作者信息
- 1. 中国科学院合肥肿瘤医院核医学科,合肥 230000
- 折叠
摘要
目的:探讨剂量降低对肿瘤患者 18F-FDG全身PET/CT图像质量和病变检出能力的影响,并探讨低剂量示踪剂的最低阈值.方法:回顾性分析 60例进行了全身PET/CT检查的肿瘤患者.通过对list-mode的PET数据进行重新编码来模拟低剂量图像.图像质量、噪声和病变可检测性采用李克特五分量表进行评估.使用健康肝脏和肿瘤病变的感兴趣区分析评估低剂量图像的摄取测量值.结果:研究发现全剂量(3.70MBq/kg)的 1/2 和 1/10 组的图像质量得分较好.对于低SUV摄取率的微小病灶,1/15剂量组和 1/30剂量分别有 8%和 38%的病灶呈假阴性.随着剂量的降低,感兴趣区的定量分析显示肝脏的SUVmax和SD逐渐增加.结论:全身PET/CT可显著降低示踪剂剂量至全剂量的 1/10(0.37MBq/kg).
Abstract
Purpose:To investigate the effect of dose reduction on 18F-FDG total-body PET/CT image quality and lesion detection ability in tumor patients,and to explore the minimum threshold of low dose tracer.Methods:A retrospective analysis was performed on 60 patients with total-body PET/CT examination.Low-dose images were simulated by recodification of list-mode PET data.Image quality,noise and lesion detectability were evaluated using 5-point Likert scales.Measurements of uptake of low-dose images were evaluated using area-of-interest analysis of healthy liver and tumor lesions.Results:My findings showed that the 1/2 and 1/10 groups of the full dose(3.70MBq/kg)had better image quality scores.For small lesions with low SUV uptake,8%and 38%of lesions in the 1/15 dose group and 1/30 dose group were false-negative,respectively.Quantitative analysis of the area of interest showed that SUVmax and SD in liver gradually increased with dose reduction(p<0.05).Conclusion:Total-body PET/CT can significantly reduce the tracer dose to 1/10 of the total dose(0.37MBq/kg).
关键词
18-氟脱氧葡糖/全身PET/CT/低剂量/肿瘤Key words
18F-FDG/total-body PET/CT/low-dose/tumor引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据