Clinical study on the feasibility of low-dose 18F-FDG whole-body PET/CT tumor imaging
Purpose:To investigate the effect of dose reduction on 18F-FDG total-body PET/CT image quality and lesion detection ability in tumor patients,and to explore the minimum threshold of low dose tracer.Methods:A retrospective analysis was performed on 60 patients with total-body PET/CT examination.Low-dose images were simulated by recodification of list-mode PET data.Image quality,noise and lesion detectability were evaluated using 5-point Likert scales.Measurements of uptake of low-dose images were evaluated using area-of-interest analysis of healthy liver and tumor lesions.Results:My findings showed that the 1/2 and 1/10 groups of the full dose(3.70MBq/kg)had better image quality scores.For small lesions with low SUV uptake,8%and 38%of lesions in the 1/15 dose group and 1/30 dose group were false-negative,respectively.Quantitative analysis of the area of interest showed that SUVmax and SD in liver gradually increased with dose reduction(p<0.05).Conclusion:Total-body PET/CT can significantly reduce the tracer dose to 1/10 of the total dose(0.37MBq/kg).
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