iTBS、tDCS对精神分裂症患者躯体-社会快感缺失的影响
Effects of iTBS and tDCS on somatosocial anhedonia in patients with schizophrenia
龚莹莹 1姜庆伟 1江庐山1
作者信息
- 1. 常州市德安医院精神科,江苏常州 213000
- 折叠
摘要
目的:观察间歇性 θ 波爆发刺激(iTBS)、经颅直流电刺激(tDCS)对精神分裂症患者躯体-社会快感缺失的影响.方法 将 91 例精神分裂症患者随机分为iTBS组 47 例、tDCS组 44 例,分别给予iTBS治疗、tDCS治疗.比较两组治疗前后躯体快感缺失量表(RPAS-C)、社会快感缺失量表(RSAS-C)、阳性与阴性症状量表(PANSS)评分以及左前脑区相关神经递质水平变化.结果 两组患者治疗后RPAS-C、RSAS-C、阴性症状、一般精神病理症状评分及PANSS总分低于治疗前(P<0.05),左前脑区Glu、DA、GABA水平高于治疗前(P<0.05),并且上述指标iTBS组患者改善程度优于tDCS组(P<0.05).结论 iTBS、tDCS治疗均可有效改善精神分裂症患者快感缺失症状,并且iTBS改善效果高于tDCS.
Abstract
Objective:To observe the effects of intermittent theta burst stimulation(iTBS)and transcranial direct current stimulation(tDCS)on somatosocial anhedonia in patients with schizophrenia.Methods:91 schizophrenic patients were randomly divided into iTBS group(47 cases)and tDCS group(44 cases),and given iTBS treatment and tDCS treatment respectively.The scores of Somatic anhedonia Scale(RPAS-C),Social Pleasure Scale(RSAS-C),Positive and Negative Symptom Scale(PANSS)and the levels of related neurotransmitters in the left forebrain were compared between the two groups before and after treatment.Results:RPAS-C,RSAS-C,negative symptom,general psychopathological symptom score and PANSS total score after treatment were lower than before treatment(P<0.05),Glu,DA and GABA levels in left forebrain area were higher than before treatment(P<0.05).The improvement of the above indexes in iTBS group was better than that in tDCS group(P<0.05).Conclusion:Both iTBS and tDCS can effectively improve anhedonia symptoms in patients with schizophrenia,and iTBS is more effective than tDCS.
关键词
间歇性θ波爆发刺激/经颅直流电刺激/精神分裂症/快感缺失/脑神经递质Key words
Intermittent theta burst stimulation/Transcranial direct current stimulation/Schizophrenia/Anhedonia/Brain neurotransmitters引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据