Application and Exploration of High-precision Microscopy Equipment in Biosafety Level-3/4 Laboratories
Biosafety is an important component of national security.In order to strengthen the construction of biosafety system and protect the public from the harm of highly pathogenic pathogenic microorganisms,China is gradually improving the construction and layout of the biosafety level 3 and 4 laboratories(BSL-3/4).High-precision microscopy equipment can enhance the process and depth of research on highly pathogenic pathogenic microorganisms,but due to factors such as lack of application protocols and risk control protocols,and unsound disinfection and sterilization methods,there are fewer domestic and international reports on the application of high-precision microscopy equipment to BSL-3/4 laboratories.Combining the reports and experiences of high-precision microscopy equipment in BSL-3/4 laboratories,the article puts forward the obstacles and risks of the application of high-precision microscopy equipment such as MPM,Cryo-EM and TEM in BSL-3/4 laboratories,and analyzes the key issues of the application plan,risk assessment and control,and disinfection and sterilization,so as to provide references and ideas for BSL-3/4 laboratories that will be equipped with high-precision microscopy equipment.
Biosafety level 3 and 4 laboratoriesMultiphoton microscopyCryo-electron microscopyTransmission electron microscopy
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