摘要
目的:探讨CA15-3、CEA和HER2在乳腺癌(BCa)中的应用价值.方法:选择 2018.10-2023.11 来我院就诊的 81 例BCa患者为研究对象,分别行CEA、CA15-3、HER2 检测,收集临床数据,分析CEA、CA15-3、HER2与年龄、绝经、肿瘤大小、转移的相关性以及比较各组CEA、CA15-3水平.结果:≤55与＞55年龄组、肿瘤直径＞2cm与≤2cm组、腋窝淋巴结转移组与非转移组、HER2 阴性与阳性组CEA的水平,经t检验比较,P分别为 0.575、0.011、0.048、0.031;以上各组CA15-3 的水平经t检验比较,P＜0.05.相关性分析示,CA-153、CEA与年龄、绝经、肿瘤大小、转移呈正相关,HER2 与以上各组不相关.回归分析示,CEA、CA15-3 和HER2 为BCa严重程度的独立危险因素.结论:CA15-3、CEA和HER2为BCa严重程度的独立危险因素,实时监测CA15-3、CEA的水平和HER2阳性比值可评估BCa临床分期、复发和转移.
Abstract
Objective:To investigate the clinical application value of CA15-3,CEA,and HER2 in breast cancer(BCa).Methods:A total of 81 BCa patients who visited our hospital between October 2018 and November 2023 were selected as subjects.The levels of CEA,CA15-3,and HER2 were measured,and clinical data were collected.The correlation of CEA,CA15-3,and HER2 with age,menopause,tumor size,and metastasis was analyzed,and the levels of CEA and CA15-3 were compared between different groups.Results:The t-test comparison of CEA levels between the groups of≤55 and>55 years,tumor diameter>2 cm and≤2 cm,axillary lymph node metastasis and non-metastasis,and HER2-negative and HER2-positive groups showed P values of 0.575,0.011,0.048,and 0.031,respectively.The levels of CA15-3 in these groups were also compared by t-test,with P<0.05 in all cases.Correlation analysis indicated that CA15-3 and CEA were positively correlated with age,menopause,tumor size,and metastasis,while HER2 was not correlated with any of these factors.Regression analysis indicated that CEA,CA15-3,and HER2 were independent risk factors for the severity of BCa.Conclusion:CA15-3,CEA,and HER2 are independent risk factors for the severity of BCa.Real-time monitoring of CA15-3,CEA levels,and HER2 positivity can help assess the clinical stage,recurrence,and metastasis of BCa.
维普
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