Objective:In this study,we established a rapid,sensitive and highly selective method for the detection of 25 fentanyl and two precursor substances by differential Raman spectroscopy.First,surface-enhanced Raman scatting(SERS)substrate of silver sol was prepared and characterized.The SERS substrate surface electromagnetic field adsorbed molecules on therough metal surface to enhance the Raman signal.Subsequently,the Raman characteristic peaks of fentanyl were assigned through theoretical calculation and experimental comparison.To explore the optimal experimental conditions,27 kinds of fentanyl-related substances in liquid and solid drugs were detected by differential Raman spectroscopy,and their stability was determined.The Raman detection range was 100～3200cm-1,the spectral resolution better than 6 cm-1,and the detection limit of the 27 fentanyl substances 0.1～25μg·kg-1.The characteristic peak of fentanyl was 1002 cm-1.Conclusion This method is fast,accurate,non-destructive,easy-to-operate,and can quickly and accurately identify and quantify fentanyl.
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