Determination of 6 N-nitrosamines in aquatic products by GC-MS/MS
To establish a gas chromatography-tandem mass spectrometry(GC-MS/MS)method for the determination of 6 N-nitrosamines(N-dimethylnitrosamines,n-methylethyl nitrosamines,n-diethylnitrosamines,n-dipropyl nitrosamines,n-dibutylnitrosamines,n-nitropiperidine)in aquatic products.The samples were extracted with acetonitrile and treated with QuEChERS principle based solid phase extraction method.Finally,the acetonitrile volume was fixed,and 5 µL was directly injected with multi-mode inlet(MMI)solvent blowdown mode,determined by GC-MS/MS multi-reaction monitoring mode(MRM),and quantitative by matrix external standard method.The six N-nitrosamines showed a good linear relationship in the range of 0.1-10 µg/L,and the correlation coefficients were all greater than 0.9990.In the analysis of actual aquatic products,the recoveries of the six N-nitrosamines were in the range of 82.9%to 108%,and the relative standard deviations(RSD)were 2.8-8.6%.The detection limit was 0.05µg/L.The method is simple,short in time,sensitive and high in recovery,and is suitable for the analysis of N-nitrosamines in aquatic products.
Gas chromatography-tandem mass spectrometry(GC-MS/MS)N-nitrosaminesMulti-mode Inlet(MMI)
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维普
