Correlation between CD27/CD57 T cells and HIV immune aging
This article retrospectively studies the immune aging of PLWHA patients and compares the expression of CD27 and CD57 on the surface of T cells between adults and elderly(uninfected with HIV),as well as between adult PLWHA patients.The results indicate that the outcomes of adult PLWHA cells in the terminal aging stage are closer to those of elderly participants rather than uninfected adult participants with HIV.When comparing immune responders and immune non responders,there was no statistically significant difference in the presence of CD27+cells among the three study groups;For the entire CD4+T cell population,the median of the INR group was higher than that of the IR group.In summary,HIV infected individuals have more T lymphocytes with molecular phenotypes related to immune aging,with a lower proportion of T cells in the early stages of aging and a higher proportion in the middle and final stages of aging.
万方数据
维普
