Effects of different modes of dexmedetomidine administration on intraoperative and postoperative period in patients with traumatic brain injury
Objective:To investigate the effects of different modes of dexmedetomidine(DEX)administration on intraoperative and postoperative patients with traumatic brain injury.Methods:108 patients with traumatic brain injury admitted to the Second Affiliated Hospital of Xingtai Medical College were selected and divided into a control group(intravenous pumping)and an experimental group(transnasal drip)according to the mode of intraoperative DEX administration,with 54 cases each.Results HR and SpO2 after anaesthesia induction(T1),tracheal intubation(T2),at extubation(T3),5 min after extubation(T4)were lower than those before induction(T0),MAP was higher than that of T0,and the magnitude of the changes in the experimental group was smaller than that of the control group(P<0.05);the NSE,GFAP,and tau were lower than those of the control group(P<0.05);the neurological function scores of the experimental group were lower than those of the control group(P<0.05);the quality of awakening was higher than that of the control group(P<0.05),and the rate of adverse reactions was lower than that of the control group.NSE,GFAP and tau of the experimental group were lower than those of the control group(P<0.05);the neurological function score of the experimental group was lower than that of the control group(P<0.05);the quality of awakening was higher than that of the control group(P<0.05),and the incidence rate of adverse reactions was lower than that of the control group.Conclusion:DEX intranasal drip facilitates intraoperative haemodynamic stability and postoperative neurological recovery.
dexmedetomidineintravenous pumpingtransnasal driphaemodynamicsneurological function
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