Difference in diagnosis of ankylosing spondylitis by diffusion-weighted imaging combined with conventional magnetic resonance imaging according to disease stages
Difference in diagnosis of ankylosing spondylitis by diffusion-weighted imaging combined with conventional magnetic resonance imaging according to disease stages
安波 1于国政 1孙好凯 1王馨
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作者信息
1. 烟台市烟台山医院放射科，烟台 264001
折叠
摘要
目的 研究弥散加权成像（DWI）结合常规磁共振成像（MRI）在强直性脊柱炎的诊断及区分炎症活动期、稳定期差异。 方法 本研究采取2018年6月到2021年6月在烟台市烟台山医院进行诊断治疗的强直性脊柱炎患者80例作为研究对象，炎症活动期患者39例，稳定期患者41例。分别对患者采取DWI结合常规MRI检查，分析两组患者DWI以及动态对比增强磁共振成像（DCE-MRI）检查各个参数之间的差异，及表观扩散系数（ADC）与达峰时间（TTP）、峰值信号强度（Sipeak）、最大上升斜率（MSI）、信号增强比率（SER）的相关性。 结果 活动组患者的ADC、TTP 、Sipeak、MSI、SER均显著高于稳定组患者，患者的ADC数值与TTP、Sipeak、MSI、SER呈正相关，联合检测对强直性脊柱炎患者的诊断特异度显著高于单独检测。 结论 DWI结合常规MRI在强直性脊柱炎诊断具有积极的意义，通过对患者的影像学诊断转化为量化指标，对于区分炎症活动期、稳定期具有积极的临床意义。 Objective To investigate the use of diffusion weighted imaging (DWI) combined with conventional magnetic resonance imaging (MRI) in diagnosing ankylosing spondylitis and the difference between active and stable stages of the condition. Methods Included in this study were 80 patients with ankylosing spondylitis diagnosed and treated in Yantaishan Hospital of Yantai City between June 2018 and June 2021, comprising 39 patients in the active stage and 41 patients in the stable stage of the disease. All patients underwent DWI and conventional MRI. The differences between the two groups in parameters of DWI and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) were evaluated. The correlations of apparent diffusion coefficient (ADC) with time to peak (TTP), peak signal intensity (Sipeak), maximum slope of increase (MSI), and signal enhancement ratio (SER) were analyzed. Results The ADC, TTP, Sipeak, MSI, and SER were significantly higher in patients with active ankylosing spondylitis than those with stable disease. Among these patients, the value of ADC of patients was positively correlated with TTP, Sipeak, MSI, and SER. Combined detection with DWI and conventional MRI yielded remarkably higher diagnostic specificity for ankylosing spondylitis compared with either alone. Conclusion DWI combined with conventional MRI can be significantly relevant in diagnosing ankylosing spondylitis. The quantitative metics derived from imaging study could be conducive to distinguishing between active and stable stages in patients with ankylosing spondylitis.
Abstract
Objective To investigate the use of diffusion weighted imaging (DWI) combined with conventional magnetic resonance imaging (MRI) in diagnosing ankylosing spondylitis and the difference between active and stable stages of the condition. Methods Included in this study were 80 patients with ankylosing spondylitis diagnosed and treated in Yantaishan Hospital of Yantai City between June 2018 and June 2021, comprising 39 patients in the active stage and 41 patients in the stable stage of the disease. All patients underwent DWI and conventional MRI. The differences between the two groups in parameters of DWI and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) were evaluated. The correlations of apparent diffusion coefficient (ADC) with time to peak (TTP), peak signal intensity (Sipeak), maximum slope of increase (MSI), and signal enhancement ratio (SER) were analyzed. Results The ADC, TTP, Sipeak, MSI, and SER were significantly higher in patients with active ankylosing spondylitis than those with stable disease. Among these patients, the value of ADC of patients was positively correlated with TTP, Sipeak, MSI, and SER. Combined detection with DWI and conventional MRI yielded remarkably higher diagnostic specificity for ankylosing spondylitis compared with either alone. Conclusion DWI combined with conventional MRI can be significantly relevant in diagnosing ankylosing spondylitis. The quantitative metics derived from imaging study could be conducive to distinguishing between active and stable stages in patients with ankylosing spondylitis.
关键词
强直性脊柱炎/炎症活动期/稳定期/动态对比增强磁共振成像/弥散加权成像
Key words
Ankylosing spondylitis/Active stage of inflammation/Stable stage/Dynamic contrast-enhanced magnetic resonance imaging/Diffusion-weighted imaging
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