回顾性分析宫颈癌患者的临床病理资料，根据患者接受根治性或术后放疗的情况分为单纯放疗组（42例）和术后放疗组（65例），依据常见不良反应事件评价标准（CTCAE V5.0），比较放射性膀胱炎（RIC）的发生概率，评价手术、病理分期、放疗总剂量和分次剂量以及膀胱和膀胱壁的放疗剂量体积参数对RIC发生率产生的影响。研究发现手术损伤导致的神经源性膀胱是造成膀胱毒性反应的可能原因，同时不排除放疗增加膀胱毒性反应的可能性。 To analyze the clinicopathological characteristics in patients with cervical cancer treated with chemoradiotherapy, or post-operational chemoradiotherapy, and to explore the high-risk factors associated with radiation-induced cystitis (RIC). 107 patients with cervical cancer was retrospectively recruited into the study who were treated with chemoradiotherapy alone, post-operational chemoradiotherapy, 42 and 65 patients, respectively. The surgical status, FIGO staging, total and fractionated doses of radiotherapy, and multiparameters including the dose and volume irradiated to the toltal bladder and bladder wall were evaluated for RIC. The combination of surgery and chemoradiotherapy may increase the incidence and severity of radiation-induced cystitis when compared to chemoradiotherapy alone suggesting that the neurogenic bladder caused by surgical injury is the main cause of bladder toxicity.
Abstract
To analyze the clinicopathological characteristics in patients with cervical cancer treated with chemoradiotherapy, or post-operational chemoradiotherapy, and to explore the high-risk factors associated with radiation-induced cystitis (RIC). 107 patients with cervical cancer was retrospectively recruited into the study who were treated with chemoradiotherapy alone, post-operational chemoradiotherapy, 42 and 65 patients, respectively. The surgical status, FIGO staging, total and fractionated doses of radiotherapy, and multiparameters including the dose and volume irradiated to the toltal bladder and bladder wall were evaluated for RIC. The combination of surgery and chemoradiotherapy may increase the incidence and severity of radiation-induced cystitis when compared to chemoradiotherapy alone suggesting that the neurogenic bladder caused by surgical injury is the main cause of bladder toxicity.
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