Clinical value of serum pentraxin3 combined with Sestrin2 in early diagnosis and prognosis evaluation of neonatal ARDS
曹玉玲 1贾云霞 1刘燕 1刘晋婷 1张翔
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作者信息
1. 山西省人民医院儿科，太原 030012
折叠
摘要
分析血清正五聚蛋白-3（pentraxin3）联合Sestrin2对新生儿急性呼吸窘迫综合征（ARDS）早期诊断及预后评估的临床价值。分析126例新生儿ARDS血清pentraxin3、Sestrin2水平变化，并评估血清pentraxin3、Sestrin2在新生儿ARDS早期诊断及预后中的价值。ARDS组新生儿血清Sestrin2水平低于对照组，血清pentraxin3水平高于对照组。不同严重程度、预后ARDS患儿血清pentraxin3、Sestrin2比较有差异。血清pentraxin3、Sestrin2均为影响ARDS新生儿预后不良的危险因素。新生儿ARDS血清pentraxin3水平升高，Sestrin2水平降低，与病情严重程度、预后均密切相关，在患儿早期诊断及预后评估中具有一定的临床价值。 To explore the clinical value of serum pentraxin3 (pentraxin3) combined with Sestrin2 in the early diagnosis and prognosis evaluation of neonatal acute respiratory distress syndrome (ARDS) . The changes of serum pentraxin3 and Sestin2 levels in 126 newborns with ARDS were analyzed, and the value of serum pentraxin3 and Sestin2 in the early diagnosis and prognosis of neonatal ARDS was evaluated. The serum level of Sestin2 in the neonates of ARDS group was lower than that of the control group, and the serum level of pentraxin3 was higher than that of the control group. There were differences in serum pentraxin3 and Sestin2 in children with ARDS with different severity and prognosis. Serum pentraxin3 and Sestin2 are risk factors for poor prognosis of newborn infants with ARDS. The increase of serum pentraxin3 level and the decrease of Sestin2 level in neonatal ARDS are closely related to the severity and prognosis of the disease and have certain clinical value in the early diagnosis and prognosis evaluation of children.
Abstract
To explore the clinical value of serum pentraxin3 (pentraxin3) combined with Sestrin2 in the early diagnosis and prognosis evaluation of neonatal acute respiratory distress syndrome (ARDS) . The changes of serum pentraxin3 and Sestin2 levels in 126 newborns with ARDS were analyzed, and the value of serum pentraxin3 and Sestin2 in the early diagnosis and prognosis of neonatal ARDS was evaluated. The serum level of Sestin2 in the neonates of ARDS group was lower than that of the control group, and the serum level of pentraxin3 was higher than that of the control group. There were differences in serum pentraxin3 and Sestin2 in children with ARDS with different severity and prognosis. Serum pentraxin3 and Sestin2 are risk factors for poor prognosis of newborn infants with ARDS. The increase of serum pentraxin3 level and the decrease of Sestin2 level in neonatal ARDS are closely related to the severity and prognosis of the disease and have certain clinical value in the early diagnosis and prognosis evaluation of children.
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