间歇性和持续性内分泌治疗前列腺癌的疗效与生活质量对比研究
Observation of intermittent and continuous hormone therapy for prostate cancer and the quality of life assessment
黄超 1邢金春 1张开颜 1李伟 1吴准1
作者信息
- 1. 361003 厦门大学附属第一医院泌尿外科
- 折叠
摘要
目的观察间歇性内分泌治疗与持续性内分泌治疗前列腺癌的疗效，评价比较两组患者的生活质量。方法回顾性分析27例采用间歇内分泌治疗和29例采用持续内分泌治疗前列腺癌患者的临床资料，以发生激素非依赖或疾病进展为观察终点，比较两组患者进展至终点时间，生活质量评价以量表 EORTC QLQC30及子量表 QLQPR25进行横断面调查。结果持续内分泌治疗组平均治疗期20.4个月，最低 PSA 平均值为0.025 ng/ml；间歇内分泌治疗组第一周期，平均治疗9.7个月，间歇8.7个月，最低 PSA 平均值为0.026 ng/ml。间歇内分泌治疗组平均进展时间为26.6个月，持续内分泌治疗组为22.4个月，两组生存曲线率的比较差异无统计学意义(P >0.05)。两组总体生活质量、治疗相关症状等方面评分均无差异。结论间歇性内分泌治疗对比持续治疗在延迟疾病进展至激素非依赖时间上没有益处，但能缓解患者经济压力。在不良反应及患者生活质量改善上两组比较无差异。
Abstract
Objective To observe and compare the effects of hormone therapy for prostate cancer with intermittent or continuous strategies,compare the quality of life (QoL)between the two groups. Methods Retrospectively collected and analysed the clinical data of intermittent (n=27)and continuous (n=29)hormone therapy for prostate cancer patients.The end point of observation was andro-gen independence or progression of disease.The time to end point between two groups were calculated and compared.A cross-sectional investigation of the QoL was taken by EORTC QLQ-C30 and its subscale QLQ-PR25. Results The continuance had a median curative period of 20.4 months,with the mean lowest PSA of 0.025 ng/ml.The intermittence took an average of 9.7 months;8.7 months for suspension in the first cycle,with the mean lowest PSA of 0.026 ng/ml.The average time to end point for intermittence was 26.6 months,compared to the 22.4 months for continuance,but the Ka-plan-Meier curve indicated no significant difference between two groups (P > 0.05 ).The general QoL and side effects of treatment were similar between two groups. Conclusions The intermittent hormone therapy did not significantly prolong the time to the progression of disease than the continu-ous therapy.But it could alleviate economic pressures for patients and no significant difference in QoL and adverse reactions was shown between two groups.
关键词
前列腺癌/间歇性内分泌治疗/生活质量Key words
Prostate cancer/Intermittent hormone therapy/Quality of life引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据